Render Target: STATIC
Render Timestamp: 2024-09-26T10:19:13.292Z
Commit: 60a5021c3a47fc24d1656fb463e2c3c41a1ad145
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. KCTD12 (D8V4J) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

KCTD12 (D8V4J) Rabbit mAb #81935

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 33
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    KCTD12 (D8V4J) Rabbit mAb recognizes endogenous levels of total KCTD12 protein.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro177 of human KCTD12 protein.

    Background

    Potassium channel tetramerization domain-containing protein 12 (KCTD12) belongs to the family of KCTD proteins, which also contains KCTD8, 12b, and 16. These proteins are auxiliary subunits of GABAB receptors (1). The principal subunit of the GABAB receptor is formed by two GABAB receptors, which bind to GABAB ligands, couple to G proteins to inhibit adenylate cyclase production, and gate ion channels (e.g., the GIRK channels) (2). The auxiliary subunits contribute to receptor desensitization. KCTD12 produces fast desensitization by uncoupling the βγ subunits of the G protein from their effector channels (3). Research studies indicate that KCTD12 represents a biomarker with diagnostic and prognostic potential for gastrointestinal stromal tumors (4).

    Database Links

    UniProt ID: Q96CX2


    Entrez-Gene Id: 115207


    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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