Kindlin-2 Antibody #13562
- WB
Supporting Data
| REACTIVITY | H M Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 77 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Kindlin-2 regulates integrin β3 mediated adhesion and migration (4,5) and contributes to Wnt signaling through interaction with β-catenin and activation of Wnt target genes (6).
Research studies indicate that kindlin-2 expression in pancreatic and gastric cancers may be indicative of poor prognosis (7,8) and that kindlin-2 may support invasiveness in breast cancer (9). Additional studies show that expression of kindlin-2 in prostate cancer cells can protect cells from cisplatin-induced cell death (10).
- Ye, F. and Petrich, B.G. (2011) Curr Opin Hematol 18, 356-60.
- Meves, A. et al. (2009) Trends Cell Biol 19, 504-13.
- Karaköse, E. et al. (2010) J Cell Sci 123, 2353-6.
- Ma, Y.Q. et al. (2008) J Cell Biol 181, 439-46.
- Bledzka, K. et al. (2010) J Biol Chem 285, 30370-4.
- Yu, Y. et al. (2012) EMBO Rep 13, 750-8.
- Mahawithitwong, P. et al. (2013) Pancreas 42, 663-9.
- Shen, Z. et al. (2012) Am J Surg 203, 222-9.
- Yu, Y. et al. (2013) Int J Cancer 133, 1368-79.
- Gong, X. et al. (2010) Cancer Lett 299, 54-62.
Limited Uses
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