LAMA1 (E4M5B) Rabbit mAb #37710
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 337 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
LAMA1 (E4M5B) Rabbit mAb recognizes endogenous levels of total LAMA1 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala2402 of human LAMA1 protein.
Background
Laminins are a family of proteins important for maintaining cellular basement membrane (BM) structure and function (1). Laminins exist as heterotrimers of alpha (LAMA), beta (LAMB), and gamma (LAMC) chains. Laminins are reported to be involved in multiple biological processes, including cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis (2). LAMA1 is thought to bind to cells via a high affinity receptor to mediate their attachment, migration, and organization of cells into tissues during embryonic development (2). Aberrant expression of LAMA1 is also associated with disease progression in patients with idiopathic pulmonary fibrosis (3).
Limited Uses
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