Lamellipodin (D8A2K) Rabbit mAb #91138
- WB
- IF
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 195 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunofluorescence (Immunocytochemistry) | 1:200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Lamellipodin (Lpd) is a member of the Mig-10/RIAM/lamellipodin (MRL) family of adaptor proteins. Lamellipodin regulates the formation of lamellipodia at the leading edge through its interaction with and recruitment of actin-modulating proteins such as Ena/VASP (3) and the Scar/WAVE complex (4). Lamellipodin and Mena cooperate with endophilin to regulate EGFR endocytosis (5). MRL proteins can also form complexes with talin and activated integrins, guiding the formation of cell protrusions and the direction of cell migration (6).
- Rottner, K. and Stradal, T.E. (2011) Curr Opin Cell Biol 23, 569-78.
- Wells, A. et al. (2013) Trends Pharmacol Sci 34, 283-9.
- Hansen, S.D. and Mullins, R.D. (2015) Elife 4, .
- Law, A.L. et al. (2013) J Cell Biol 203, 673-89.
- Vehlow, A. et al. (2013) EMBO J 32, 2722-34.
- Lagarrigue, F. et al. (2015) Nat Commun 6, 8492.
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