LAMP3/CD208 (E6E5U) XP® Rabbit mAb (BSA and Azide Free) #88687
- WB
- IHC
- IF
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 70, 140 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
Formulation
Storage
Specificity / Sensitivity
LAMP3/CD208 (E6E5U) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total LAMP3 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro257 of human LAMP3/CD208 protein.
Background
Lysosome-associated membrane proteins (LAMPs) are a family of proteins present predominantly on the membrane of lysosomes. Five members have been identified so far (LAMP1, LAMP2, LAMP3, CD68/Macrosialin/LAMP4, and BAD-LAMP/LAMP5). LAMP proteins are involved in many different aspects of cell biology and can influence cellular processes, such as phagocytosis, autophagy, lipid transport, and aging. Their expression varies among different tissues (1). LAMP3, also known as CD-LAMP and CD208, is highly expressed only in certain cell types and differentiation stages. LAMP3 is specifically expressed by human dendritic cells (DCs) upon activation and therefore serves as a marker of human DC maturation, but is not expressed by DCs in mouse (2-4). Its expression is associated with poor prognosis of certain tumors, and the locus where it is encoded was identified as a risk factor for Parkinson's disease (PD) (5).
Limited Uses
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