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Render Timestamp: 2024-12-20T11:04:08.856Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-12-16 15:01:10.228
Product last modified at: 2024-12-17T08:00:57.363Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. LAMP5 (F9Q8X) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

LAMP5 (F9Q8X) Rabbit mAb #19230

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 31
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:10 - 1:50
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    LAMP5 (F9Q8X) Rabbit mAb recognizes endogenous levels of total LAMP5 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LAMP5 protein.

    Background

    Lysosome-associated membrane glycoproteins (LAMPs) are a family of proteins present predominantly on the membrane of lysosomes. Five members have been identified so far (LAMP1, LAMP2, LAMP3, CD68/Macrosialin/LAMP4, and BAD-LAMP/LAMP5). LAMP proteins are involved in many different aspects of cell biology and can influence cellular processes, such as phagocytosis, autophagy, lipid transport, and aging. Their expression varies among different tissues (1). Differing from its family members, LAMP5, also called brain and dendritic cell-associated LAMP (BAD-LAMP), is almost exclusively expressed in the central nervous system (CNS). LAMP5 acts as a marker for a subset of GABAergic interneurons where it functions in synaptic transmission and synaptic plasticity, and has been shown to play a role in sensorimotor processing in the brain and spinal cord (2,3). Loss of LAMP5 positive interneurons can be seen in Alzheimer’s disease, potentially implicating these cells in neurodegeneration (4). In addition to its role in the CNS, LAMP5 expression has been implicated in several cancer types, including gastric cancer, where it promotes metastatic potential of gastric cancer cells, and mixed lineage leukemia, where it acts as a suppressor of autophagy (5,6).

    Database Links

    UniProt ID: Q9UJQ1


    Entrez-Gene Id: 24141


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