Render Target: STATIC
Render Timestamp: 2025-03-19T11:03:19.274Z
Commit: 779953b12a5930618aae6aca7c87fb286faeb1d7
XML generation date: 2025-03-07 13:10:06.246
Product last modified at: 2025-02-17T16:30:09.545Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

LINGO-1 Antibody #49389

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 98
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    LINGO-1 Antibody recognizes endogenous levels of total LINGO-1 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu400 of human LINGO-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Leucine-rich repeat and immunoglobulin domain-containing protein 1 (LINGO-1) is a potent negative modulator of neuronal processes, including neuronal survival, axonal integrity, oligodendrocyte differentiation, and myelination (1-5). LINGO-1, Nogo receptor (NgR), and p75 neurotrophin receptor (p75NTR), or TNF receptor orphan Y (TROY) form a tripartite receptor complex, which activates RhoA/ROCK signaling and is responsible for the inhibition effect of myelin- associated factors (6,7). LINGO-1 is abundantly expressed in the brain and is implicated in various neurodegenerative disorders, such as Essential tremor, multiple sclerosis, and Parkinson’s disease (8-11). Recently, LINGO-1 was reported to bind directly to amyloid precursor protein (APP), promoting its degradation through lysosomal proteolysis (12). This research study implicated that LINGO-1 plays a critical role in the pathophysiology of Alzheimer's disease.
    For Research Use Only. Not For Use In Diagnostic Procedures.
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