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LINGO-1 Antibody #49389

Filter:
  • WB
Western Blotting Image 1: LINGO-1 Antibody
Western blot analysis of extracts from rat, mouse, and human brain using LINGO-1 Antibody.

To Purchase # 49389

Cat. # Size Qty. Price
49389S 100 µl
$306

Product Specifications

REACTIVITY H M R
SENSITIVITY Endogenous
MW (kDa) 98
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • R-Rat 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

LINGO-1 Antibody recognizes endogenous levels of total LINGO-1 protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu400 of human LINGO-1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

Background

Leucine-rich repeat and immunoglobulin domain-containing protein 1 (LINGO-1) is a potent negative modulator of neuronal processes, including neuronal survival, axonal integrity, oligodendrocyte differentiation, and myelination (1-5). LINGO-1, Nogo receptor (NgR), and p75 neurotrophin receptor (p75NTR), or TNF receptor orphan Y (TROY) form a tripartite receptor complex, which activates RhoA/ROCK signaling and is responsible for the inhibition effect of myelin- associated factors (6,7). LINGO-1 is abundantly expressed in the brain and is implicated in various neurodegenerative disorders, such as Essential tremor, multiple sclerosis, and Parkinson’s disease (8-11). Recently, LINGO-1 was reported to bind directly to amyloid precursor protein (APP), promoting its degradation through lysosomal proteolysis (12). This research study implicated that LINGO-1 plays a critical role in the pathophysiology of Alzheimer's disease.
For Research Use Only. Not for Use in Diagnostic Procedures.
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