Render Target: STATIC
Render Timestamp: 2024-12-26T11:40:53.302Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:59:52.475
Product last modified at: 2024-09-30T08:01:37.674Z
Cell Signaling Technology Logo
View Featured Offers >>
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. Liprin α1 (E7D7W) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Liprin α1 (E7D7W) Rabbit mAb #30787

Filter:
  • WB
  • IP
  • IF

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 150
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50
    Immunofluorescence (Immunocytochemistry) 1:100 - 1:400

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Liprin α1 (E7D7W) Rabbit mAb recognizes endogenous levels of total Liprin α1 protein. A band of unknown origin at 78 kDa is detected by western blot. No specific signal was observed in fixed frozen mouse tissue by immunofluorescence.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro819 of human Liprin α1 protein.

    Background

    The Liprin α family contains four members (Liprin α1/2/3/4) in vertebrates, which are core synaptic scaffolding proteins essential for synapse assembly and maturation (1). Liprin α proteins form homodimers and heterodimers with Liprin β proteins, and all four genes encoding Liprin α family members undergo alternative splicing in humans and mice (2,3). Liprin α1 is ubiquitously expressed and regulated in an activity-dependent manner. Liprin α1 is degraded either in response to CaMKII phosphorylation or via the E3 ubiquitin ligase anaphase-promoting complex (APC) (4). At the synapse, it participates in both presynaptic and postsynaptic functions, including active zone assembly, neurotransmitter release, and synaptic cargo transport, as well as acetylcholine receptor (AChR) clustering and organization of postsynaptic machinery (1,2). In squamous cell carcinoma of head and neck (HNSCC) cell lines, Liprin α1 has been shown to regulate biological processes related to protein trafficking, cell-cell contacts, and cell-substrate contacts. Liprin α1 also affects the distribution of cell surface β1 integrin, thereby promoting focal adhesion turnover and controlling cell edge dynamics, supporting its additional role in cancer cell invasion and metastasis pathways (5,6). 

    Database Links

    UniProt ID: Q13136


    Entrez-Gene Id: 8500


    Limited Uses

    Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.