Render Target: STATIC
Render Timestamp: 2024-12-26T12:13:08.149Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-08-01 15:27:20.042
Product last modified at: 2024-06-27T13:36:17.152Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464
  1. Products /
  2. Primary Antibodies /
  3. Liprin β1 Antibody

Liprin β1 Antibody #18409

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 140
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Liprin β1 Antibody recognizes endogenous levels of total Liprin β1 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser510 of human Liprin β1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Liprins are a family of proteins known to function as LAR (leukocyte common antigen-related) transmembrane protein tyrosine phosphatase-interacting proteins (1). This interaction has been studied in connection to both axon guidance and mammary gland development (1,2). Liprin β1, a member of this family, is a widely expressed, multivalent cytosolic protein. Liprin β1 has been found to homodimerize at the N terminus and to heterodimerize with Liprin α1 and the metastasis-associated protein S100A4 at the C terminus (1,2). The interaction with S100A4 is believed to both inhibit its phosphorylation and to modulate complex formation with Liprin α1, resulting in a change in LAR cell adhesion properties, thus promoting cell motility and tumor metastasis (2). Liprin β1 has also been shown to have higher expression levels and to associate with KANK proteins in melanoma and to be a potential regulator of lymphatic vessel integrity (3,4).

    Database Links

    UniProt ID: Q86W92


    Entrez-Gene Id: 8496


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    For Research Use Only. Not For Use In Diagnostic Procedures.
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