LRRC15 (E4X8J) Rabbit mAb #50546
- WB
- IHC
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 80-100 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunohistochemistry (Paraffin) | 1:50 - 1:200 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu100 of human LRRC15 protein.
Background
LRRC15 (Leucine-rich repeat-containing protein 15, LIB) is a transmembrane protein belonging to the LRR family of proteins involved in cell–cell and cell–ECM (extracellular matrix) interactions (1-4). It has been identified as a marker for TGF-β–driven CAFs (cancer-associated fibroblasts), which are associated with immunotherapy resistance (3,4). LRRC15 is highly expressed in multiple solid tumor types, with low expression in normal tissues, making it a good therapeutic candidate for cancers with high stromal content, such as pancreatic cancer, non–small cell lung cancer (NSCLC), and triple-negative breast cancer (3,4).
Limited Uses
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