Ly-6C (E7L3S) Rabbit mAb #37872
- WB
Supporting Data
| REACTIVITY | M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 10 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Ly-6 proteins have been widely used as differentiation markers on hematopoietic cells. The ability to isolate and express specific Ly-6 antibodies through hybridoma technology has allowed researchers to identify unique proteins (1). These proteins are expressed on subsets of immune cells at different stages of development, such as T cells, B cells, monocytes, granulocytes, and macrophages (1-5).
Ly-6C1 and Ly-6C2 are two distinct genes located adjacent to each other within the Ly-6 gene complex. They share >95% similarity in their genomic and protein sequences, and with a nearly identical structure, expression profile, and reactivity to antibodies, they are collectively known as Ly-6C. A propeptide is removed to form the mature Ly-6C protein, a 10 kDa GPI-linked surface protein expressed on mouse monocyte/macrophage cells, endothelial cells, neutrophils, and some T cell subsets. Ly-6C is most frequently used to distinguish inflammatory states of monocyte populations in mice (6).
Limited Uses
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