MAP1S (E3P5Z) Rabbit mAb #57187
- WB
Supporting Data
| REACTIVITY | M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 125, 142 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
MAP1S contributes to mitochondria stabilization by interacting with mitochondrion-associated leucine-rich PPR-motif containing protein (LRPPRC). MAP1S regulates ubiquitination processes like autophagosome biogenesis and protein clearance. These processes are MAP1S isoform-specific (5). An increased level of MAP1S enhances autophagy to remove p62-associated aggresomes and dysfunctional organelles that trigger DNA double-strand breaks and genome instability (6).
Limited Uses
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