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Render Timestamp: 2024-10-31T10:00:15.435Z
Commit: 23cb9f61fe67e1e9093fd644a533c4ff516a6463
XML generation date: 2024-09-30 01:58:21.681
Product last modified at: 2024-09-30T08:00:53.760Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. MAP7 (E8K7O) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MAP7 (E8K7O) Rabbit mAb #53626

Filter:
  • WB
  • IF

    Supporting Data

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 110
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunofluorescence (Frozen) 1:800 - 1:3200
    Immunofluorescence (Immunocytochemistry) 1:200 - 1:800

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MAP7 (E8K7O) Rabbit mAb recognizes endogenous levels of total MAP7 protein.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MAP7 protein.

    Background

    MAP7 is a member of the Microtubule-Associated Proteins (MAPs) that regulates the stability and function of the cytoskeleton in cells (1). MAP7 facilitates the transport of organelles, such as mitochondria and lysosomes, via recruitment of kinesin-1 (2). This role of MAP7 in organelle transport occurs in neuronal and non-neuronal cells, including Drosophila oocytes, and in S2 cells and mammalian muscle cells (4,5). In addition to promoting organelle transport via kinesin-1 recruitment, MAP7 also contributes to the morphogenesis of axons that is domain-specific, whereas the full-length MAP7 promotes branch maturation, N- and P- domains are responsible for branch formation, and the C-terminal kinesin-interacting domain contributes to the axonal growth (3,6). MAP7 and the paralog MAP7D1 directly interact with disheveled, an effector of the Wnt5a β-catenin-independent pathway, regulating the microtubule remodeling, cell migration, and cell adhesion in HeLa cells (7). MAP7 is considered a biomarker in a model to treat multiple sclerosis based on the tolerogenic dendritic cells induced by vitamin D3 (8).

    Database Links

    UniProt ID: Q14244


    Entrez-Gene Id: 9053


    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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