Render Target: STATIC
Render Timestamp: 2024-12-30T10:51:12.156Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:56:06.184
Product last modified at: 2024-12-17T18:58:07.363Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MARCKSL1 (D4I9P) Rabbit mAb #59568

Filter:
  • WB

    Supporting Data

    REACTIVITY H M
    SENSITIVITY Endogenous
    MW (kDa) 40
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MARCKSL1 (D4I9P) Rabbit mAb recognizes endogenous levels of total MARCKSL1 protein.

    Species Reactivity:

    Human, Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro186 of human MARCKSL1 protein.

    Background

    Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS/ MARCKS-like protein 1/ MacMARCKS/ MLP/ MRP) is a widely expressed membrane-bound PKC substrate involved in multiple cellular functions (1). MARCKSL1 is a MARCKS homolog that also serves as a substrate for PKC, and regulates cytoskeletal dynamics, migration, adhesion, and proliferation.
    In response to phosphorylation by JNK, MARCKSL1 regulates migration and actin dynamics in neuronal and prostate cancer cells (2). In the developing retina, MARCKSL1 regulates cell proliferation, and its expression decreases as retinal development progresses (3). Researchers have shown that MARCKSL1 may serve as a prognostic marker in lymph node-negative breast cancer (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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