Render Target: STATIC
Render Timestamp: 2024-12-20T11:10:33.781Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-12-16 11:04:13.885
Product last modified at: 2024-12-17T08:00:58.178Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Matrin 3 (F4Q5F) Rabbit mAb #45457

Filter:
  • WB
  • IP
  • IF

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 125
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Simple Western™ 1:10 - 1:50
    Immunoprecipitation 1:100
    Immunofluorescence (Frozen) 1:50 - 1:100
    Immunofluorescence (Immunocytochemistry) 1:400 - 1:1600

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Matrin 3 (F4Q5F) Rabbit mAb recognizes endogenous levels of total matrin 3 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human matrin 3 protein.

    Background

    Matrin 3 (MATR3) is a nuclear protein with two zinc finger domains, two RNA recognition motifs, and two intrinsically disordered regions. This protein is able to bind both DNA and RNA sequences and is a critical component of the nuclear matrix (1-4). MATR3 was initially implicated in human disease through its identification in a family with an autosomal dominant form of vocal cord and pharyngeal distal myopathy (5). Since then, exome sequencing has identified over a dozen point mutations in the MATR3 gene that have been linked to familial amyotrophic lateral sclerosis (ALS) and combined ALS/frontotemporal dementia (6-8). Moreover, abnormal MATR3 abundance, localization, and aggregation have been reported in motor neurons of patients with sporadic ALS (9,10).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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