Name: MAVS Antibody
Price: 129.00 USD
Availability: InStock

Filter:

WB
IF

Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	75, 52
SOURCE	Rabbit

Application Key:

WB-Western Blotting
IF-Immunofluorescence

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunofluorescence (Immunocytochemistry)	1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

MAVS Antibody detects endogenous levels of total human MAVS protein. The bands detected at 52 and 75 kDa correlate with those described by Seth et al. (2005).

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxyl terminus of human MAVS. Antibodies were purified by affinity chromatography.

Background

The mitochondrial antiviral signaling protein (MAVS, VISA) contributes to innate immunity by triggering IRF-3 and NF-κB activation in response to viral infection, leading to the production of IFN-β (1). The MAVS protein contains an N-terminal CARD domain and a C-terminal mitochondrial transmembrane domain. The MAVS adaptor protein plays a critical and specific role in viral defenses (2). MAVS acts downstream of the RIG-I RNA helicase and viral RNA sensor, leading to the recruitment of IKKε, TRIF, and TRAF6 (3,4). Some viruses have evolved strategies to circumvent these innate defenses by using proteases that cleave MAVS to prevent its mitochondrial localization (5,6).

Database Links

UniProt ID: Q7Z434

Entrez-Gene Id: 57506

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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MAVS Antibody #3993