Render Target: STATIC
Render Timestamp: 2024-12-23T11:50:43.306Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-11-26 23:01:10.098
Product last modified at: 2024-12-02T09:00:10.419Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MB21D2 (F6Z9B) Rabbit mAb #87678

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 56
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MB21D2 (F6Z9B) Rabbit mAb recognizes endogenous levels of total MB21D2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MB21D2 protein.

    Background

    Mab-21 domain-containing protein 2 (MB21D2), also known as C3orf59, belongs to a protein family of cGAS/DncV-like nucleotidyltransferase (CD-NTase) enzymes involved in a variety of cellular processes, including cell survival, proliferation, and migration (3). MB21D2 is an intracellular E-cadherin binder that carries a recurrent Q311E mutation (1,4). Both wild-type (WT) and Q311E mutant MB21D2 have been identified as being frequently overexpressed in lung, head, and neck cancers, and may mediate pro-oncogenic activities by promoting epithelial-mesenchymal transition (EMT)/cancer stemness (2-4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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