Render Target: STATIC
Render Timestamp: 2024-12-20T11:47:45.692Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-11-18 16:03:13.238
Product last modified at: 2024-12-13T23:00:10.063Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MCT4/SLC16A3 (F2K6A) Rabbit mAb #81569

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 40
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MCT4/SLC16A3 (F2K6A) Rabbit mAb recognizes endogenous levels of total MCT4/SLC16A3 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human MCT4/SLC16A3 protein.

    Background

    MCT4, also known as MOT4 or SLC16A3, is a multi-pass transmembrane monocarboxylate transporter (MCT) protein encoded by the gene SLC16A3 (1,2). MCT4 is reported to be expressed in white (glycolytic) muscle cells (3,4), astrocytes (5), activated macrophages (6), and cancer cells (2). The primary role of MCT4 is lactate exportation, which is adapted to the release of lactate from glycolytic cells (8,9). In the tumor microenvironment, MCT4 mediated lactate secretion promotes M2 macrophage polarization and suppresses T cell function (10). MCT4 inhibition increases the efficacy of immune checkpoint blockade and is a potential target to reverse tumor resistance to immunotherapy (11,12).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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