Render Target: STATIC
Render Timestamp: 2024-12-20T11:32:11.794Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-20 06:15:07.112
Product last modified at: 2024-12-17T13:15:14.373Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

MCUR1 Antibody #13706

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 23
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MCUR1 Antibody recognizes endogenous levels of total MCUR1 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala305 of human MCUR1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Mitochondrial Calcium Uniporter Regulator 1 (MCUR1) is a mitochondrial inner membrane protein involved in the uptake of calcium. This multi-pass protein contains two transmembrane domains with both amino- and carboxy-termini projecting into the same mitochondrial intermembrane space (1). Research studies indicate that reduction in MCUR1 activity results in decreased mitochondrial Ca2+ uptake, while overexpression of MCUR1 results in increased mitochondrial calcium levels (1). MCUR1 protein directly interacts with mitochondrial calcium uniporter (MCU) and plays an essential role in the regulation of calcium uptake and maintenance of mitochondrial calcium homeostasis (1). Regulation of MCU by MCUR1 may be critical for a variety of cellular functions, including signal transduction, bioenergetics, and cell death and survival (2).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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