Render Target: STATIC
Render Timestamp: 2024-12-20T11:18:02.366Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-10-22 13:16:11.897
Product last modified at: 2024-11-02T17:30:08.177Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

MEIS1/2 Antibody #12744

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Transfected Only
    MW (kDa) 50, 70
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MEIS1/2 Antibody recognizes transfected levels of total MEIS1 and MEIS2 proteins.

    Species Reactivity:

    Human

    The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.

    Species predicted to react based on 100% sequence homology:

    Mouse

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MEIS1 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Hox, Pbx, and Meis are families of transcription factors that bind DNA via their homeodomains. Members from each family form heterodimers to give rise to complexes with unique DNA binding specificities. Homeodomain-containing proteins are frequently involved in normal developmental processes but can also be associated with tumorigenic states (1). MEIS proteins belong to the three amino acid loop extension (TALE) homeobox-containing transcription factor family. MEIS1 has been associated with leukemogenesis and neuroblastoma (2,3), while MEIS2 is known to play an important role in the transcriptional program that is induced in normal pancreatic development (4) and cardiogenesis (5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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