Render Target: STATIC
Render Timestamp: 2024-11-13T10:20:58.723Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-04-05 20:50:08.203
Product last modified at: 2024-05-30T07:10:09.670Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

MERS-CoV Nucleocapsid Protein Antibody #73039

Filter:
  • WB

    Supporting Data

    REACTIVITY Vir
    SENSITIVITY Transfected Only
    MW (kDa) 55
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • Vir-Virus 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MERS-CoV Nucleocapsid Protein Antibody recognizes transfected levels of total MERS-CoV nucleocapsid protein.

    Species Reactivity:

    Virus

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro382 of MERS-CoV nucleocapsid protein. Antibodies are purified by peptide affinity chromatography.

    Background

    Middle East Respiratory Syndrome (MERS) is a contagious viral respiratory infection, whose causative agent was identified as the MERS-related coronavirus (MERS-CoV) (1,2). MERS-CoV is a single-stranded mRNA betacoronavirus. Similar to other infectious coronaviruses (e.g., SARS-CoV-2), the MERS-CoV genome encodes four key structural proteins (spike, envelope, membrane, and nucleocapsid) that make up the virion particle, in addition to at least 10 smaller open reading frames (ORFs) that encode the non-structural (accessory) proteins involved in viral replication (3,4). Nucleocapsid protein is the primary protein involved in packaging the viral genome; however, its functions extend beyond its role in nucleocapsid formation. It may be translationally modified by host enzymes (5,6), and has been reported to influence viral transcription and replication, virion assembly, and the host response to viral infection, through effects on cell cycle, translation, and the innate immune response (7).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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