Render Target: STATIC
Render Timestamp: 2024-12-26T11:39:17.246Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-11-18 16:03:15.747
Product last modified at: 2024-11-19T09:00:17.582Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

METTL5 (F4E9V) Rabbit mAb #78409

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 26
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    METTL5 (F4E9V) Rabbit mAb recognizes endogenous levels of total METTL5 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu13 of human METTL5 protein.

    Background

    Methyltransferase-like protein 5 (METTL5) forms a stable complex with TRMT112 in order to catalyze N6-methyladenosine on the 18S rRNA at position 1832 (1). METTL5 can affect the global translation rate, pluripotency, differentiation, and neural development (2-4). High expression of METTL5 has been described in lung adenocarcinoma where it contributes to epithelial-mesenchymal transition (5,6). In pancreatic cancer, METTL5 promotes Myc translation to drive progression (6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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