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Render Timestamp: 2024-11-21T12:42:15.864Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:57:45.685
Product last modified at: 2024-09-30T08:02:21.791Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. MNX1/HB9 (E3W8D) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MNX1/HB9 (E3W8D) Rabbit mAb #41983

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 55
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MNX1/HB9 (E3W8D) Rabbit mAb recognizes endogenous levels of total MNX1/HB9 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser231 of human MNX1/HB9 protein.

    Background

    Motor neuron and pancreas homeobox protein 1 (MNX1 or Homeobox protein HB9) is a homeobox transcription factor that has conserved functions in motor neuron differentiation and pancreas development.  The mammalian central nervous system (CNS) is composed of specialized neurons, and the specification of neuronal identity in the CNS is determined early in development by spatially-specified expression of cell-intrinsic determinants, many of which are transcription factors (1). MNX1/HB9 is one such transcription factor. In response to developmental signals, MNX1/HB9 is expressed transiently to drive differentiation of ventral progenitor cells into somatic motor neurons (2,3). Mutations in the gene encoding human MNX1/HB9 are linked to Currarino syndrome, a developmental disease caused by dorsal-ventral patterning defects resulting in presacral tumors, sacral agenesis, and anorectal malformation in patients suffering from this disease (4,5).  

    Database Links

    UniProt ID: P50219


    Entrez-Gene Id: 3110


    Limited Uses

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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