Render Target: STATIC
Render Timestamp: 2024-11-21T13:34:00.725Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:57:50.543
Product last modified at: 2024-11-06T19:30:12.291Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MOG (D5B4C) Rabbit mAb #45268

Filter:
  • WB
  • IP
  • IF

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 46, 35, 28, 23, 14
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    • IF-Immunofluorescence 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50
    Immunofluorescence (Frozen) 1:200 - 1:800

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    For a carrier free (BSA and azide free) version of this product see product #36647.

    Protocol

    Specificity / Sensitivity

    MOG (D5B4C) Rabbit mAb recognizes endogenous levels of total MOG protein. This antibody cross-reacts with other human MOG isoforms that contain the carboxy terminus of human MOG isoform 1.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MOG protein.

    Background

    Myelin-oligodendrocyte glycoprotein (MOG) is a type I membrane bound glycoprotein of the immunoglobulin superfamily that is enriched in the outer lamella of the myelin sheath (1). The myelin sheath is a multi-layered membrane structure composed of oligodendrocytes that increases the conduction velocity of axonal impulses. The specific function of MOG is unknown, but MOG’s structure and expression during later stages of myelinogenesis suggests a role in myelin sheath maturation and maintenance (2). MOG may be an autoimmune target in central nervous system inflammatory diseases such as multiple sclerosis (MS) (3). Induction of MOG autoimmunity is also used as an experimental model for MS as injections of MOG peptide or recombinant protein in rodent models causes severe neurological disease that recapitulates several clinical features of MS (4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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