MRP1/ABCC1 (D5C1X) Rabbit mAb (BSA and Azide Free) #97760
- WB
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 170-220 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.
Formulation
For standard formulation of this product see product #72202
Storage
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Although MRP1/ABCC1 is generally expressed in normal tissue, upregulation of MRP1/ABCC1 has been found in a variety of solid tumors, including small cell lung cancer, breast cancer, and prostate cancer (1,4,5). Research studies show that overexpression of MRP1/ABCC1 facilitates the elimination of therapeutic agents from cancer cells and confers drug resistance in those patients. Research studies also show that elevated expression of MRP1/ABCC1 is a negative prognostic marker for breast cancer and small cell lung cancer, as the level of MRP1/ABCC1 is predictive of the response and toxicity of chemotherapeutic agents in those patients (6-10).
- Cole, S.P. et al. (1992) Science 258, 1650-4.
- Pajic, M. et al. (2005) Cancer Lett 228, 241-6.
- Deeley, R.G. and Cole, S.P. (2006) FEBS Lett 580, 1103-11.
- Atalay, C. et al. (2006) Tumour Biol 27, 309-18.
- Sánchez, C. et al. (2011) Prostate 71, 1810-7.
- Nooter, K. et al. (1997) Br J Cancer 76, 486-93.
- Hsia, T.C. et al. (2002) Lung 180, 173-9.
- Kuo, T.H. et al. (2003) Nucl Med Biol 30, 627-32.
- Sánchez, C. et al. (2009) Prostate 69, 1448-59.
- Vulsteke, C. et al. (2013) Ann Oncol 24, 1513-25.
Limited Uses
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