Render Target: STATIC
Render Timestamp: 2024-11-21T13:03:30.937Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 02:00:07.608
Product last modified at: 2024-09-30T08:01:55.529Z
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MS4A4A (F2E6F) Rabbit mAb #33202

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 25
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MS4A4A (F2E6F) Rabbit mAb recognizes endogenous levels of total MS4A4A protein. A band of unknown origin is detected at 70 kDa by western blotting.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val130 of human MS4A4A protein.

    Background

    Membrane-spanning 4-domains subfamily A member 4A (MS4A4A) is a member of a class of MS4A genes encoding four-transmembrane-spanning proteins (1,2). MS4A4A expression is enriched in human and mouse macrophages (3,4). Its expression in macrophages may be induced during macrophage development and activation (4). MS4A4A, via its interaction with the β-glucan receptor, Dectin-1, may contribute to macrophage-mediated production of proinflammatory cytokines and reactive oxygen species by activation of the Syk signaling pathway (4). Interestingly, MS4A4A, as well as other members of the MS4A gene cluster, is genetically linked to late-onset Alzheimer’s disease, suggesting that MS4A4A-dependent macrophage/microglia might contribute to neurodegenerative disease progression (5,6).
    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.