Render Target: STATIC
Render Timestamp: 2024-12-26T12:05:15.738Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:59:45.068
Product last modified at: 2024-09-30T08:01:34.041Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MS4A7 (E3E1A) Rabbit mAb #80817

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 20
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    MS4A7 (E3E1A) Rabbit mAb recognizes endogenous levels of total MS4A7 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MS4A7 protein.

    Background

    Membrane-spanning 4-domains subfamily A member 7 (MS4A7) is a member of a class of MS4A genes encoding four transmembrane-spanning proteins (1,2). MS4A7 is involved in signal transduction as a component of a multimeric receptor complex. Expression of the MS4A7 gene is primarily restricted to microglia in the brain (3). Interestingly, MS4A7, as well as other members of the MS4A gene cluster, is genetically linked to late-onset Alzheimer’s disease, suggesting that MS4A-dependent microglia might contribute to neurodegenerative disease progression (4).     
    For Research Use Only. Not For Use In Diagnostic Procedures.
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