MST3 Antibody #3723
- WB
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Mammalian Sterile 20-like kinase 3 (MST3, STK24) is ubiquitously expressed as a longer MST3b isoform and a shorter MST3a protein lacking a portion of the amino-terminal region (5). The widely expressed MST3a protein regulates apoptosis and cell motility, as well as neuronal migration during CNS development (6,7). MST3 phosphorylates and activates the NDR protein kinases that regulate cell cycle progression and cell morphology (8). Autophosphorylation of MST3 at Thr178 is required for in vitro kinase activity, and alteration of this residue inhibits MST3 regulation of cell migration in vivo (7). The brain-specific MST3b protein is activated by nerve growth factor or inosine and localizes to neurons where it helps regulate axon growth and regeneration (9).
- Dan, I. et al. (2001) Trends Cell Biol 11, 220-30.
- Creasy, C.L. et al. (1996) J Biol Chem 271, 21049-53.
- Lee, K.K. and Yonehara, S. (2002) J Biol Chem 277, 12351-8.
- Zhao, B. et al. (2011) Nat Cell Biol 13, 877-83.
- Zhou, T.H. et al. (2000) J Biol Chem 275, 2513-9.
- Tang, J. et al. (2014) J Neurosci 34, 7425-36.
- Lu, T.J. et al. (2006) J Biol Chem 281, 38405-17.
- Stegert, M.R. et al. (2005) Mol Cell Biol 25, 11019-29.
- Lorber, B. et al. (2009) Nat Neurosci 12, 1407-14.
Limited Uses
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