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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464
  1. Products /
  2. Primary Antibodies /
  3. MT-ATP6 Antibody

MT-ATP6 Antibody #70262

Filter:
  • WB
  • IP
Western Blotting Image 1: MT-ATP6 Antibody
Western blot analysis of extracts from HeLa cells, cultured in the absence (-) or presence (+) of ethidium bromide, using MT-ATP6 Antibody (upper) and GAPDH (D16H11) XP® Rabbit mAb #5174 (lower). Ethidium bromide-treated cells are depleted of mitochondrial DNA (mtDNA) and mtDNA-encoded proteins, including MT-ATP6.
1/4

To Purchase # 70262

Cat. # Size Qty. Price
70262S 100 µl
$306

Supporting Data

REACTIVITY H M R
SENSITIVITY Endogenous
MW (kDa) 20
SOURCE Rabbit
Application Key:
  • WB-Western Blotting 
  • IP-Immunoprecipitation 
Species Cross-Reactivity Key:
  • H-Human 
  • M-Mouse 
  • R-Rat 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000
Immunoprecipitation 1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

MT-ATP6 Antibody recognizes endogenous levels of total MT-ATP6 protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Polyclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MT-ATP6 protein. Antibodies are purified by peptide affinity chromatography.

Background

Mitochondrially-encoded ATP Synthase Membrane Subunit 6 (MT-ATP6) is a product of MT-ATP6, one of 13 protein-encoding genes in the mitochondrial genome. MT-ATP6 comprises one subunit of the transmembrane F1FO ATP synthase (Complex V), which catalyzes the final step of oxidative phosphorylation in the electron transport chain (1). Numerous mutations in the MT-ATP6 gene have been identified that lead to defects in oxidative phosphorylation. Many of these are strongly associated with distinct disease states, including Leigh syndrome (2) and Charcot-Marie-Tooth (CMT) disease (3).

Database Links

UniProt ID: P00846


Entrez-Gene Id: 4508


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For Research Use Only. Not For Use In Diagnostic Procedures.
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