MT-ATP8 (E2W1A) Rabbit mAb #96857

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Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	9
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:50

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

MT-ATP8 (E2W1A) Rabbit mAb recognizes endogenous levels of total MT-ATP8 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro65 of human MT-ATP8 protein.

Background

Mitochondrially-encoded ATP Synthase Membrane Subunit 8 (MT-ATP8) is a product of MT-ATP8, one of 13 protein-encoding genes in the human mitochondrial genome (1). MT-ATP8 comprises one subunit (ATP synthase F_O subunit 8) of mitochondrial ATP synthase (Complex V), the inner mitochondrial enzyme that catalyzes the final step of oxidative phosphorylation in the electron transport chain (2). Numerous mutations in MT-ATP8 have been identified that have deleterious effects on ATP synthase function, some of which manifest as debilitating neuronal and/or neuromuscular diseases, including epilepsy, schizophrenia, autism, ataxia, and various cardiomyopathies (3), underscoring the importance of healthy mitochondrial function to organismal health.

Database Links

UniProt ID: P03928

Entrez-Gene Id: 4509

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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