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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. MUC16 (E9E1Z) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

MUC16 (E9E1Z) Rabbit mAb #97326

Filter:
  • WB
Western Blotting Image 1: MUC16 (E9E1Z) Rabbit mAb
Western blot analysis of extracts from OVCAR-3 and SK-OV-3 cells using MUC16 (E9E1Z) Rabbit mAb (upper) or GAPDH (D16H11) XP® Rabbit mAb #5174 (lower). Negative expression of MUC16 protein in SK-OV-3 cells is consistent with the predicted expression pattern.
1/1

To Purchase # 97326

Cat. # Size Qty. Price
97326T 20 µl
$168
97326S 100 µl
$371

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa) 200-270
Source/Isotype Rabbit IgG
Application Key:
  • WB-Western Blotting 
Species Cross-Reactivity Key:
  • H-Human 
  • Related Products

Product Information

Product Usage Information

Application Dilution
Western Blotting 1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

MUC16 (E9E1Z) Rabbit mAb recognizes endogenous levels of total MUC16 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr12484 of human MUC16 protein.

Background

Mucins are a family of macromolecules that line and protect the respiratory epithelium from microbes and pollutants in the local environment. Of the family members that are known to date, some are produced in a cell type and tissue-specific manner, suggesting distinct biological roles for members. Some members polymerize after secretion to form gel-like substances that coat the epithelial layer (1). MUC16 is a member of the mucin family, which are high molecular weight, O-glycosylated proteins that play an important role in forming mucous barriers (2) and are found on the apical surface of the epithelia. It contains an extracellular domain at its amino acid terminus, a large tandem repeat, and a transmembrane domain with a short cytoplasmic domain. MUC16 has been linked to lung cancer (3) and ovarian cancer (4). It provides protective, lubricating barriers against particles and infectious agents at mucosal surfaces (5).

Database Links

UniProt ID: Q8WXI7


Entrez-Gene Id: 94025


Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.
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