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Product last modified at: 2025-03-25T11:45:10.192Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77

MUC5AC (E3O9I) XP® Rabbit mAb #61193

Filter:
  • IHC
  • IF
Immunohistochemistry Image 1: MUC5AC (E3O9I) XP® Rabbit mAb
Immunohistochemical analysis of paraffin-embedded human colon carcinoma using MUC5AC (E3O9I) XP® Rabbit mAb.

To Purchase # 61193

Cat. # Size Qty. Price
61193T 20 µl
$168
61193S 100 µl
$392

Supporting Data

REACTIVITY H
SENSITIVITY Endogenous
MW (kDa)
Source/Isotype Rabbit IgG
Application Key:
  • IHC-Immunohistochemistry 
  • IF-Immunofluorescence 
Species Cross-Reactivity Key:
  • H-Human 
  • Related Products

Product Information

Product Usage Information

Application Dilution
IHC Leica Bond 1:400
Immunohistochemistry (Paraffin) 1:400
Immunofluorescence (Immunocytochemistry) 1:400

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

For a carrier free (BSA and azide free) version of this product see product #60100.

Protocol

Specificity / Sensitivity

MUC5AC (E3O9I) XP® Rabbit mAb recognizes endogenous levels of total MUC5AC protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro2712 of human MUC5AC protein.

Background

Mucins are a family of macromolecules that line and protect the respiratory epithelium from microbes and pollutants in the local environment. Of the family members that are known to date, some are produced in a cell type and tissue-specific manner, suggesting distinct biological roles for members. Some members polymerize after secretion to form gel-like substances that coat the epithelial layer. MUC5AC and MUC5B are members of the family that polymerize in this manner. Others do not polymerize, and others yet, have a transmembrane domain and remain physically attached to the epithelia (1). While it is known that mucins are protective to the respiratory epithelium, it has been reported that changes in expression of mucins are associated with several forms of lung disease such as cystic fibrosis, COPD, asthma, pulmonary fibrosis, and others (1-4). Multiple epithelial malignancies have been described to show changes in expression, localization, and glycosylation of MUC5AC. This wide association with multiple malignancy types has led to the emergence of MUC5AC as both a prognostic and therapeutic target for cancer (5).
For Research Use Only. Not For Use In Diagnostic Procedures.
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