MX2 (E7Y8H) Rabbit mAb #43924

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Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	80
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

MX2 (E7Y8H) Rabbit mAb recognizes endogenous levels of total MX2 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn175 of human MX2 protein.

Background

Mx2 (MxB) is a dynamin-like GTPase that is highly upregulated by IFN-α and IFN-β and upregulated to a lesser extent by IFN-γ (1). It was identified as a potent cell-autonomous HIV restriction factor (2). Mx2 functions as an HIV restriction factor by blocking infection at the late post-entry step through prevention of nuclear accumulation and chromosomal integration (2). HIV restriction by Mx2 is dictated through the capsid region of the viral Gag protein (2).

Database Links

UniProt ID: P20592

Entrez-Gene Id: 4600

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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