Myosin VI Antibody #9200
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Product Name
- WB
Inquiry Info. # 9200
Please see our recommended alternatives.
Supporting Data
| REACTIVITY | H Dg |
| SENSITIVITY | Endogenous |
| MW (kDa) | 150 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- Dg-Dog
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Myosin VI is an unconventional minus-end-directed myosin involved in the transport of vesicles and organelles within the cell, endocytosis, and organelle biogenesis (3-6). The movement of myosin VI and its cargo along actin filaments is unique among myosin family members in its mechanism; its tail domain structure allows it to take larger than predicted steps along the actin filament (reviewed in 1,7).
Myosin VI has been shown to regulate the polarized delivery of proteins to specialized subcellular locations, including the delivery of EGFR to the leading edge of migrating cells (8), as well as the delivery of specialized axonal proteins in neurons (9). Myosin VI has also been shown to mediate activity of the tumor suppressor p53 during DNA damage (10,11).
- Sweeney, H.L. and Houdusse, A. (2010) Cell 141, 573-82.
- Nambiar, R. et al. (2010) Cell Mol Life Sci 67, 1239-54.
- Bond, L.M. et al. (2011) Mol Biol Cell 22, 54-65.
- Aschenbrenner, L. et al. (2004) Mol Biol Cell 15, 2253-63.
- Loubéry, S. et al. (2012) Traffic 13, 665-80.
- Ameen, N. and Apodaca, G. (2007) Traffic 8, 998-1006.
- Spudich, J.A. and Sivaramakrishnan, S. (2010) Nat Rev Mol Cell Biol 11, 128-37.
- Chibalina, M.V. et al. (2010) Traffic 11, 1290-303.
- Lewis, T.L. et al. (2011) PLoS Biol 9, e1001021.
- Jung, E.J. et al. (2006) Mol Cell Biol 26, 2175-86.
- Cho, S.J. and Chen, X. (2010) J Biol Chem 285, 27159-66.
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