Nav1.7 Antibody #14573
- WB
- IP
Supporting Data
| REACTIVITY | M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 230-250 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
There are 9 mammalian alpha subunits, named Nav1.1-Nav1.9 (5). These alpha subunits differ in tissue specificity and biophysical functions (6,7). Seven of these subunits are essential for the initiation and propagation of action potentials in the central and peripheral nervous system while Nav1.4 and Nav1.5 are mainly expressed in skeletal muscle and cardiac muscle (8,9). Mutations in these alpha channel subunits have been identified in patients with epilepsy, seizure, ataxia, sensitivity to pain, and cardiomyopathy (reviewed in 10).
The Nav1.7 alpha subunit (Nav1.7, SCN9A) plays an important role in nociception signaling and is essential for acute, inflammatory, and neuropathic pain perception (11,12). Mutations in the corresponding SCN9A gene are associated with primary erythermalgia, autosomal recessive congenital indifference to pain, and paroxysmal extreme pain disorder (13-15). Mutations in SCN9A cause the GEFSP7 form of generalized epilepsy with febrile seizures, and are implicated in many cases of Dravet syndrome, a severe form of pediatric epileptic encephalopathy (16).
- Catterall, W.A. (2000) Neuron 26, 13-25.
- Yu, F.H. and Catterall, W.A. (2003) Genome Biol 4, 207.
- Isom, L.L. et al. (1994) Neuron 12, 1183-94.
- Yu, F.H. et al. (2003) J Neurosci 23, 7577-85.
- Goldin, A.L. et al. (2000) Neuron 28, 365-8.
- Plummer, N.W. and Meisler, M.H. (1999) Genomics 57, 323-31.
- Goldin, A.L. (2001) Annu Rev Physiol 63, 871-94.
- George, A.L. et al. (1992) Ann Neurol 31, 131-7.
- Ou, Y. et al. (2002) Neurogastroenterol Motil 14, 477-86.
- Meisler, M.H. and Kearney, J.A. (2005) J Clin Invest 115, 2010-7.
- Minett, M.S. et al. (2012) Nat Commun 3, 791.
- Minett, M.S. et al. (2014) PLoS One 9, e104458.
- Yang, Y. et al. (2004) J Med Genet 41, 171-4.
- Cox, J.J. et al. (2010) Hum Mutat 31, E1670-86.
- Fertleman, C.R. et al. (2006) Neuron 52, 767-74.
- Mulley, J.C. et al. (2013) Epilepsia 54, e122-6.
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