NCKIPSD (E6Z3N) Rabbit mAb #89661
- WB
- IP
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 83 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val716 of human NCKIPSD protein.
Background
NCKIPSD (NCK-interacting protein with SH3 domain), also known as SPIN90, is a cytoskeletal adaptor protein involved in organization of the actin cytoskeleton and actin-based cell motility (1). Downregulation of NCKIPSD expression in breast cancer stroma is correlated with decreased survival. NCKIPSD regulates microtubule acetylation in cancer-associated fibroblasts (CAFs) (2). NCKIPSD also plays a role in modulating signaling in the central nervous system (3).
Limited Uses
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