NCoR1 Antibody #5948
- WB
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 270 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Recent genetic studies in mice have not only corroborated the wealth of biochemical studies involving NCoR1 but have also provided significant insight regarding the function of NCoR1 in mammalian development and physiology. Although it has been observed that loss of Ncor1 does not affect early embyonic development, likely due to compensation by Smrt, embryonic lethality ultimately results during mid-gestation, largely due to defects in erythropoesis and thymopoesis (6). Another study demonstrated that the NDs of NCoR1 are critical for its ability to function in a physiological setting as a transcriptional repressor of hepatic THR and Liver X Receptor (LXR) (7).
- Chen, J.D. and Evans, R.M. (1995) Nature 377, 454-7.
- Hörlein, A.J. et al. (1995) Nature 377, 397-404.
- Jones, P.L. and Shi, Y.B. (2003) Curr Top Microbiol Immunol 274, 237-68.
- Downes, M. et al. (1996) Nucleic Acids Res 24, 4379-86.
- Wong, C.W. and Privalsky, M.L. (1998) Mol Cell Biol 18, 5724-33.
- Jepsen, K. et al. (2000) Cell 102, 753-63.
- Astapova, I. et al. (2008) Proc Natl Acad Sci U S A 105, 19544-9.
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