Render Target: STATIC
Render Timestamp: 2024-11-12T10:29:28.485Z
Commit: 3c1f305a63297e594ac8d7bb5424007d592d68be
XML generation date: 2024-08-01 15:24:39.270
Product last modified at: 2024-08-28T22:15:07.701Z
View Featured Offers >>
1% for the planet logo
PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464
  1. Products /
  2. Primary Antibodies /
  3. NDRG2 Antibody

NDRG2 Antibody #5667

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 45
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    NDRG2 Antibody recognizes endogenous levels of total NDRG2 protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys25 of human NDRG2 protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    The NDRG (N-Myc downstream-regulated gene) family consisting of NDRG1, NDRG2, NDRG3, and NDRG4 are structurally related proteins with roles in cell proliferation, differentiation, apoptosis, stress responses, and cell migration/metastasis (1-3). NDRG1 was originally identified as a protein that was upregulated in N-Myc knockout mice (1). Proteins in the NDRG family, particularly NDRG1 and NDRG2, have been reported to be down-regulated in various cancer tissues and have been suggested to function as a tumor suppressors (4,5).
    Expression of NDRG1 and NDRG2 is up-regulated by p53 and HIF-1, and contributes to apoptosis driven by those pathways (6-11). NDRG1 and NDRG2 are also associated with pathological conditions in the nervous system. Nonsense mutation of the NDRG1 gene has been shown to cause hereditary motor and sensory neuropathy-Lom (HMSNL), which is supported by studies demonstrating the role of NDRG1 in maintaining myelin sheaths and axonal survival (12, 13). Elevated expression of NDRG2 has been observed with Alzheimer's disease (14). Both NDGR1 and NDGR2 are phosphorylated at multiple sites by Akt and/or SGK1, although the precise physiological role of this phosphorylation is not known (15, 16).
    1. Shimono, A. et al. (1999) Mech Dev 83, 39-52.
    2. Qu, X. et al. (2002) Mol Cell Biochem 229, 35-44.
    3. Zhou, R.H. et al. (2001) Genomics 73, 86-97.
    4. Yao, L. et al. (2008) Acta Biochim Biophys Sin (Shanghai) 40, 625-35.
    5. Ellen, T.P. et al. (2008) Carcinogenesis 29, 2-8.
    6. Kurdistani, S.K. et al. (1998) Cancer Res 58, 4439-44.
    7. Park, H. et al. (2000) Biochem Biophys Res Commun 276, 321-8.
    8. Stein, S. et al. (2004) J Biol Chem 279, 48930-40.
    9. Cangul, H. (2004) BMC Genet 5, 27.
    10. Wang, L. et al. (2008) Cell Physiol Biochem 21, 239-50.
    11. Liu, N. et al. (2008) Nucleic Acids Res 36, 5335-49.
    12. Kalaydjieva, L. et al. (2000) Am J Hum Genet 67, 47-58.
    13. Okuda, T. et al. (2004) Mol Cell Biol 24, 3949-56.
    14. Mitchelmore, C. et al. (2004) Neurobiol Dis 16, 48-58.
    15. Murray, J.T. et al. (2004) Biochem J 384, 477-88.
    16. Burchfield, J.G. et al. (2004) J Biol Chem 279, 18623-32.

    Database Links

    UniProt ID: Q9UN36


    Entrez-Gene Id: 57447


    Limited Uses

    Except as otherwise expressly agreed in a writing signed by a legally authorized representative of CST, the following terms apply to Products provided by CST, its affiliates or its distributors. Any Customer's terms and conditions that are in addition to, or different from, those contained herein, unless separately accepted in writing by a legally authorized representative of CST, are rejected and are of no force or effect.

    Products are labeled with For Research Use Only or a similar labeling statement and have not been approved, cleared, or licensed by the FDA or other regulatory foreign or domestic entity, for any purpose. Customer shall not use any Product for any diagnostic or therapeutic purpose, or otherwise in any manner that conflicts with its labeling statement. Products sold or licensed by CST are provided for Customer as the end-user and solely for research and development uses. Any use of Product for diagnostic, prophylactic or therapeutic purposes, or any purchase of Product for resale (alone or as a component) or other commercial purpose, requires a separate license from CST. Customer shall (a) not sell, license, loan, donate or otherwise transfer or make available any Product to any third party, whether alone or in combination with other materials, or use the Products to manufacture any commercial products, (b) not copy, modify, reverse engineer, decompile, disassemble or otherwise attempt to discover the underlying structure or technology of the Products, or use the Products for the purpose of developing any products or services that would compete with CST products or services, (c) not alter or remove from the Products any trademarks, trade names, logos, patent or copyright notices or markings, (d) use the Products solely in accordance with CST Product Terms of Sale and any applicable documentation, and (e) comply with any license, terms of service or similar agreement with respect to any third party products or services used by Customer in connection with the Products.

    For Research Use Only. Not For Use In Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
    All other trademarks are the property of their respective owners. Visit our Trademark Information page.