Render Target: STATIC
Render Timestamp: 2024-12-20T11:42:07.296Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:55:15.100
Product last modified at: 2024-12-17T18:53:45.943Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

Neogenin (D7M8E) Rabbit mAb #39447

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 210
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    Neogenin (D7M8E) Rabbit mAb recognizes endogenous levels of total neogenin protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile1250 of human neogenin protein.

    Background

    Neogenin is a member of the Deleted in Colorectal Cancer (DCC) receptor family. It acts as an attractive axon guidance receptor in response to netrin, and as a repellent receptor when interacting with RGMa (1,2). Neogenin also regulates adhesion and tissue organization, such as bone formation, mammary gland morphogenesis, and skeletal myofiber development, by interacting with secreted netrins (3-5). In addition, neogenin is a key regulator of adult neurogenesis by synchronizing neuroblast migration and differentiation (6). Neogenin expression has been found to be associated with cellular phenotype in cancer. In breast cancer, neogenin expression is inversely correlated with cancer grade (7), while in gastric cancer, up regulation of neogenin was found to increase cell proliferation and motility (8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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