NF-κB1 p105/p50 (5D10D11) Mouse mAb #13681
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50 Active form, 120 Precursor |
| Source/Isotype | Mouse IgG2a |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Following IKK-mediated phosphorylation of p105 NF-κB at multiple sites (Ser921, 923, 927, and 932) on its carboxy-terminus, β-TrCP (SCF) mediated processing produces the 50 kDa active form p50 (12,13).
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- Heissmeyer, V. et al. (2001) Mol Cell Biol 21, 1024-35.
- Orian, A. et al. (2000) EMBO J 19, 2580-91.
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