NFAT4 Antibody #4998
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 140 to 190 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
The antigen sequence used to produce this antibody shares 100% sequence homology with the species listed here, but reactivity has not been tested or confirmed to work by CST. Use of this product with these species is not covered under our Product Performance Guarantee.
Species predicted to react based on 100% sequence homology:
Source / Purification
Background
NFAT4 upregulates the expression of several cytokine genes and activation markers and downregulates expression of CD154 in naive CD4(+) T cells. Furthermore, NFAT4 augments expression of IFN-gamma and TNF-alpha in helper T-cells 1 (Th1 cells) and attenuates expression of IL-4 and IL-5 in helper T-cells 2 (Th2 cells) (6).
- Northrop, J.P. et al. (1993) J Biol Chem 268, 2917-23.
- Hogan, P.G. et al. (2003) Genes Dev 17, 2205-32.
- Crabtree, G.R. and Olson, E.N. (2002) Cell 109 Suppl, S67-79.
- Okamura, H. et al. (2004) Mol Cell Biol 24, 4184-95.
- Shaw, K.T. et al. (1995) Proc Natl Acad Sci U S A 92, 11205-9.
- Chen, J. et al. (2003) J. Immunol. 170, 3109-3117.
Limited Uses
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