NIPSNAP1 (D1Y6S) Rabbit mAb #13226
- WB
- IP
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 29 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
Interaction of NIPSNAP1 with the putative oncogene Ca2+-selective transient receptor potential vanilloid channel 6 (TRPV6) inhibits channel function at the cell membrane (1,2). In prostate cancer cells, alterations in chromatin structure that result in corresponding NIPSNAP1 gene inactivation have been implicated in the malignant phenotype (3).
In mouse brain, NIPSNAP has been shown to interact with mitochondrial amyloid precursor protein (APP), which may facilitate the effect of APP on mitochondrial function. (4). NIPSNAP1 expression is also altered in the brains of phenylketonuria (PKU) mice, implying a role for NIPSNAP1 in PKU-related cognitive impairment (5). NIPSNAP1 has also been implicated in pain transmission through its interaction with the neuropeptide nocistatin (NST) in mouse spinal cord (6).
- Schoeber, J.P. et al. (2008) Pflugers Arch 457, 91-101.
- Lehen'kyi, V. et al. (2012) J Physiol 590, 1369-76.
- Malhotra, A. et al. (2013) Cancer Biol Ther 14, 840-52.
- Tummala, H. et al. (2010) Eur J Neurosci 31, 1926-34.
- Surendran, S. et al. (2005) Neurochem Int 46, 595-9.
- Okuda-Ashitaka, E. et al. (2012) J Biol Chem 287, 10403-13.
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