Render Target: STATIC
Render Timestamp: 2024-12-26T11:58:54.741Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-12-24 23:02:08.465
Product last modified at: 2024-12-25T09:00:52.608Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. NLRP2 (F3C9H) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

NLRP2 (F3C9H) Rabbit mAb #48980

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 120
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    NLRP2 (F3C9H) Rabbit mAb recognizes endogenous levels of total NLRP2 protein. This antibody cross-reacts with a 60 kDa protein of unknown identity in some cell lysates.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gln679 of human NLRP2 protein.

    Background

    NOD-like receptor family pyrin domain-containing 2 (NLRP2) is a member of the NLR family, which is composed of proteins that can form inflammasomes and/or act as sensors that drive inflammation and cell death (1,2). They accomplish this by promoting maturation of downstream targets, such as caspase-1, IL-1b, IL-18, IL-37, and gasdermin D (3). NLRP2 has been shown to interact with apoptosis-associated speck-like protein containing a CARD (ASC), and its expression is induced in mouse dorsal root ganglia following treatment with complete Freund's adjuvant, which causes inflammation and pain (4,5). NLRP2 is also essential for embryonic development in mice, with depletion leading to early arrest (6).

    Database Links

    UniProt ID: Q9NX02


    Entrez-Gene Id: 55655


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    For Research Use Only. Not For Use In Diagnostic Procedures.
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