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Render Timestamp: 2024-11-22T11:34:27.563Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 02:00:09.456
Product last modified at: 2024-11-05T13:30:16.926Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
  1. Products /
  2. Primary Antibodies /
  3. NLRP6 (E2S8A) Rabbit mAb
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

NLRP6 (E2S8A) Rabbit mAb #10650

Filter:
  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 99
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    NLRP6 (E2S8A) Rabbit mAb recognizes endogenous levels of total NLRP6 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human NLRP6 protein.

    Background

    NLR family pyrin domain containing 6 (NLRP6, NALP6, PYPAF5), a member of the NOD-like receptor (NLR) family, acts as an innate immune sensor of microbe-associated molecular patterns (1). NLRP6 is primarily expressed in epithelial cells, mainly in the gastrointestinal tract (1,2,5). Like other NLR family members, NLRP6 is composed of three domains: a pyrin domain (PYD), a nucleotide-binding domain (NBD), and a leucine-rich repeat (LRR) domain (5). Upon activation, NLRP6 may form an inflammasome, a multiprotein complex that functions as a sensor of damage-associated molecular patterns (1-5). The NLRP6 inflammasome is involved in the activation of caspase-1 and subsequent processing of pro-inflammatory cytokines IL-1β and IL-18 as part of the innate immune response (1-5). NLRP6 may also play a role in regulating intestinal homeostasis (2-5).

    Database Links

    UniProt ID: P59044


    Entrez-Gene Id: 171389


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    For Research Use Only. Not For Use In Diagnostic Procedures.
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