NRROS (E4B2D) Rabbit mAb #58142
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 90-100 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
NRROS has also been shown as a key regulator of transforming growth factor beta-1 (TGF-β1) required for microglia function in the nervous system (3,4). Microglia and other macrophages within the central nervous system (CNS) have roles in neural development, inflammation, and homeostasis (3,5). NRROS is required for normal gene expression driving microglial development and function (6-8). Mutation and dysregulation of NRROS in mouse models and humans leads to severe brain disease owing to oxidative tissue damage in the CNS (6-8). NRROS is also involved in Toll-like receptor (TLR) signaling. NRROS ability to inhibit NF-κB activation downstream of TLR activation and subsequent decreased cytokine production is likely related indirectly to its role in the TGF-β1 pathway (9).
- Noubade, R. et al. (2014) Nature 509, 235-9.
- Xia, X. et al. (2021) Int Immunopharmacol 96, 107625.
- Leavy, O. (2014) Nat Rev Immunol 14, 357.
- Dong, X. et al. (2020) Am J Hum Genet 106, 559-569.
- Wong, K. et al. (2017) Nat Immunol 18, 633-641.
- Smith, C. et al. (2020) Acta Neuropathol 139, 947-951.
- Macintosh, J. et al. (2022) Neurogenetics 23, 151-156.
- Qin, Y. et al. (2018) Cell 174, 156-171.e16.
- Liu, J. et al. (2013) Biochem Biophys Res Commun 434, 28-34.
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