Render Target: STATIC
Render Timestamp: 2024-12-20T10:57:14.135Z
Commit: f2d32940205a64f990b886d724ccee2c9935daff
XML generation date: 2024-09-30 01:59:06.314
Product last modified at: 2024-10-30T18:30:09.918Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

NUP210 (E9A5G) Rabbit mAb #50047

Filter:
  • WB

    Supporting Data

    REACTIVITY H M R Mk
    SENSITIVITY Endogenous
    MW (kDa) 210
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 
    • Mk-Monkey 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    NUP210 (E9A5G) Rabbit mAb recognizes endogenous levels of total NUP210 protein.

    Species Reactivity:

    Human, Mouse, Rat, Monkey

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro290 of human NUP210 protein.

    Background

    The nuclear pore complex (NPC) is a multi-subunit protein channel that spans the nuclear envelope and is responsible for the nucleocytoplasmic trafficking of RNA, proteins, and ribonucleoproteins (1,2). Nucleoporin 210 kDa (NUP210), also referred to as nuclear pore glycoprotein 210 (gp210), is one of the three integral membrane proteins of the NPC that have been shown to link the complex to the nuclear envelope (3,4). NUP210 is recruited in later stages of the nuclear pore assembly and is expressed in a cell-type specific manner (5). NUP210 expression has been shown to be induced during myogenic and neural differentiation, and its addition to NPCs is needed for activation of essential cell differentiation genes (6). It has also been shown that NUP210 is required for proper muscle structural gene expression at NPCs by acting as a scaffold for the Mef2C transcriptional complex (7). More recently, NUP210 was identified as a metastasis susceptibility gene for estrogen receptor-positive breast cancer (8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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