Render Target: STATIC
Render Timestamp: 2024-12-13T11:37:49.646Z
Commit: 611277b6de3cd1bb065350b6ef8d63df412b7185
XML generation date: 2024-08-01 15:28:27.342
Product last modified at: 2024-11-21T21:15:09.689Z
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PDP - Template Name: Polyclonal Antibody
PDP - Template ID: *******59c6464

OAS2 Antibody #54155

Filter:
  • WB

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 70
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    OAS2 Antibody recognizes endogenous levels of total OAS2 protein. This antibody cross-reacts with an unidentified protein of 29 kDa in some cell lines.

    Species Reactivity:

    Human

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala330 of human OAS2 protein. Antibodies are purified by peptide affinity chromatography.

    Background

    2’-5’-oligoadenylate synthetase 2 (OAS2) is an enzyme induced by type 1 interferon that plays a key role in the host antiviral innate immune response (1,2). The OAS family of proteins includes OAS1, OAS2, OAS3, and OASL in humans (3). OAS2 is activated by cytosolic dsRNA and its enzymatic activity generates the second messenger 2’-5’-linked oligoadenylate. These 2’-5’-linked oligoadenylates bind to the ribonuclease RNase L, which then degrades viral and cellular RNA in an effort to curb viral replication (1). Research studies have shown that components of the OAS-RNase L system, including OAS2, are highly upregulated in response to SARS-CoV-2 infection, suggesting a role for this antiviral pathway in the pathogenesis of SARS-CoV-2 (4,5).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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