Name: OAS3 Antibody
Price: 302.00 USD
Availability: InStock

Filter:

WB
IP

Supporting Data

REACTIVITY	H
SENSITIVITY	Endogenous
MW (kDa)	120
SOURCE	Rabbit

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:100

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

OAS3 Antibody recognizes endogenous levels of total OAS3 protein. This antibody detects an 18 kDa band of unknown origin in some cell lines.

Species Reactivity:

Human

Source / Purification

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human OAS3 protein. Antibodies are purified by peptide affinity chromatography.

Background

The 2'-5'-oligoadenylate synthetase (OAS) family of interferon-induced proteins play an important role in cellular innate immune response (1-4). When activated by double-stranded RNA, these proteins polymerize ATP into 2′-5′-linked oligomers (2,3,5). These 2’-5’-linked oligoadenylates bind to the ribonuclease RNase L, which then degrades viral and cellular RNA (2,3,5). In humans, the OAS family of proteins includes OAS1, OAS2, OAS3, and OASL (1-3). OAS3 is required to activate RNase L and to restrict the replication of four different human viruses (5). These findings suggest that OAS3 may provide a target for antiviral therapies (4,5).

Database Links

UniProt ID: Q9Y6K5

Entrez-Gene Id: 4940

Limited Uses

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For Research Use Only. Not For Use In Diagnostic Procedures.

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OAS3 Antibody #41440