Render Target: STATIC
Render Timestamp: 2024-11-21T13:39:37.039Z
Commit: 5c4accf06eb7154018ba3f54329c7590f97f534a
XML generation date: 2024-09-30 01:59:06.099
Product last modified at: 2024-11-11T13:30:10.414Z
1% for the planet logo
PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

OLR1/LOX1 (E9C5A) Rabbit mAb #57946

Filter:
  • WB
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 35-42
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:50 - 1:200

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    For a carrier free (BSA and azide free) version of this product see product #20752.

    Protocol

    Specificity / Sensitivity

    OLR1/LOX1 (E9C5A) Rabbit mAb recognizes endogenous levels of total OLR1/LOX1 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val230 of human OLR1/LOX1 protein.

    Background

    Oxidatively modified low-density lipoprotein (Ox-LDL) causes endothelial cell dysfunction and activation and contributes to atherosclerosis. Oxidized low-density lipoprotein receptor 1 (OLR1), also known as lectin-like oxidized LDL receptor 1 (LOX1), was cloned and identified as a cell membrane receptor for Ox-LDL in vascular endothelial cells (1). In addition, research studies show that OLR1/LOX1 is one of the most overexpressed genes in human polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) that regulate immune responses in cancer. OLR1/LOX1 is a specific marker of human PMN-MDSC (2). Furthermore, OLR1/LOX1 was shown to be upregulated in esophageal cancer. OLR1/LOX1 deficiency stimulates autophagic cell death, inhibiting esophageal cancer development (3).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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