ORF1p (D3W9O) Rabbit mAb #88701
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 42 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Simple Western™ | 1:10 - 1:50 |
Storage
Protocol
Specificity / Sensitivity
Species Reactivity:
Source / Purification
Background
While normally silenced, ORF1p is expressed in many types of cancers (9-12). Recently, it has been found that ORF1p can become phosphorylated and that this event impacts its ability to promote retrotransposition. This creates a novel dynamic to which the host could actively affect L1 replication through various signaling cascades (13).
- Kazazian, H.H. and Moran, J.V. (1998) Nat Genet 19, 19-24.
- Malik, H.S. et al. (1999) Mol Biol Evol 16, 793-805.
- Wilhelm, M. and Wilhelm, F.X. (2001) Cell Mol Life Sci 58, 1246-62.
- Scott, A.F. et al. (1987) Genomics 1, 113-25.
- Moran, J.V. et al. (1996) Cell 87, 917-27.
- Feng, Q. et al. (1996) Cell 87, 905-16.
- Martin, S.L. and Bushman, F.D. (2001) Mol Cell Biol 21, 467-75.
- Kolosha, V.O. and Martin, S.L. (1997) Proc Natl Acad Sci U S A 94, 10155-60.
- Lee, E. et al. (2012) Science 337, 967-71.
- Rodić, N. et al. (2015) Nat Med 21, 1060-4.
- Doucet-O'Hare, T.T. et al. (2015) Proc Natl Acad Sci U S A 112, E4894-900.
- Chen, L. et al. (2012) Breast Cancer Res Treat 136, 129-42.
- Rodić, N. et al. (2014) Am J Pathol 184, 1280-6.
- Cook, P.R. et al. (2015) Proc Natl Acad Sci U S A 112, 4298-303.
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